According to data from the CDC, the prevalence of obesity in children and adolescents was 19.7% between the years 2017-20.  The numbers are on a gradual rise, which goes to show that this is an alarming condition that’s not stopping anytime soon.

Based on these complications, a recent presenter at ENDO 2022 facilitated saying that adolescent boys who are obese or overweight and have risks of insulin resistance were found to have a “lower testicular volume” compared to a healthy weight adolescent boy.

The presenter, Rossalla Cannarella, MD, a Ph.D. candidate at the department of clinical and experimental medicine at the University of Catania in Italy, said that male infertility adheres to multiple etiological factors. However, to this day, no conclusive reasoning depicts the exact cause behind male infertility.

Further reiterating her presentation, Cannarella reported that one of the most common contributors to idiopathic male infertility is linked cases of childhood overweight or obesity.

She suggested that excess body fat deposition leads to risks of hyperinsulinemia or insulin resistance in the body, both of which are associated with reduced testicular volume in adolescent boys and one that gets worse with age.

In their research, Cannarella and her colleagues looked into multiple factors, including:

  • Obesity
  • Hyperinsulinemia
  • Insulin resistance
  • Type-2 diabetes

These factors were recorded in a cohort of adolescent teen boys who were 16 years and younger than that.

For the assessment, the subjects were made to undergo an oral glucose tolerance test, following which the testicular volume, fasting glycemia, age, BMI, insulin levels, and HbA1C levels were collected around 120 minutes after the test.

The results from the above findings were then compared with the levels recorded in boys under the age of 9 and, in boys between the years of 9-14 years, and in boys between the ages of 14 and 16. None of the placebo group underwent the oral glucose tolerance test.

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