In terms of revenue, global alpha-1 antitrypsin deficiency (AATD) augmentation therapy market was valued at US$ 1217.34 Mn in 2020 and is anticipated to reach US$ 2052.93 Mn by 2029 growing at a CAGR of 6.0% over the forecast period (2021 – 2029). The study analyses the market in terms of revenue across all the major regions, which have been bifurcated into countries.

The alpha1 antitrypsin deficiency (AATD) is a hereditary disorder. This disorder is characterized by a lack or deficiency of alpha1 antitrypsin in the blood, a protein that is important for the proper and healthy functioning of the lungs. The respiratory deficiency was first identified by Carl-Bertil Laurell and Sten Eriksson (Laurell and Eriksson 1963) in 1963. They discovered a link between low plasma serum AAT levels and pulmonary emphysema symptoms. As the understanding of the genetic abnormalities grew with time, AAT deficiency came to be recognized as one of the most common hereditary disorders globally. The alpha1-antitrypsin deficiency (AATD) therapy involves extracting AAT protein from a healthy donor’s blood plasma for increasing AAT levels in the respiratory tract of patients. This treatment has also been found to delay the progression of emphysema, minimize the frequency of exacerbations and improve recovery speed, a factor that has led to its increasing preference among both the patients and healthcare providers. Hence, the increasing prevalence of respiratory disorders is one of the key factors driving the growth of the alpha-1 antitrypsin deficiency (AATD) augmentation therapy market. Moreover, efficient distribution of augmentation therapy drugs by leading manufacturers is also found to be propelling the market growth with a remarkable rate.

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Recent advancements in diagnostic tools for genetic diseases have made revolutionary progress in the diagnosis and treatment of AATD. Patients with AATD require regular regimented care, for which augmentation therapy is specifically preferred treatment option. Hence, improved diagnostic techniques for genetic disorders, coupled with rising prevalence of AATD are significantly boosting the global alpha-1 antitrypsin deficiency (AATD) augmentation therapy market. Moreover, manufacturers and researchers are also currently striving to find effective ways to provide the therapy with more flexibility in their treatment regimen. Various established pharmaceutical players such as Biocerna LLC and Octapharma are engaged in conducting research on new and existing molecules for the betterment of AATD treatment scenario.

Some of the players operating in the global alpha-1 antitrypsin deficiency (AATD) augmentation therapy market are Abeona Therapeutics Inc., Baxter, CSL, Grifols, S.A., Kamada Pharmaceuticals, Takeda Pharmaceutical Company Limited, and other market participants.

End User Outlook:

Based on end-user, the market is bifurcated into hospitals and clinics, physician’s office, outpatient infusion centers and others. Hospitals and clinics segment dominated the alpha-1 antitrypsin deficiency (AATD) augmentation therapy market, in terms of its share in 2020 due to rising patients of COPD and increased number of patients coming in through reimbursement programs such as Medicare. Also clinics segment is growing at the same market share owing to the growing number of patients opting for specialty clinics when it comes to treatment of AATD.

Application Outlook:

Based on applications, the market is segmented into emphysema, Alpha-1, and others. Emphysema accounted for the highest market share in 2020 in the global alpha-1 antitrypsin deficiency (AATD) augmentation therapy market. Due to the discovery of the structure and function of the AAT protein, and its subsequent isolation and purification, allowing augmentation therapy aimed at preventing progression of the emphysema, has significantly led to the growth of this segment.

Region Outlook:

Based on the regions, North America accounted for a significant share in the global alpha-1 antitrypsin deficiency (AATD) augmentation therapy market in 2020. The dominance is attributable to the rising prevalence of the disease in the U.S and strategic presence of key companies in this region. For instance, leading AATD company, Grifols, S.A., received FDA U.S.A’s approval for A1AT genotyping test for the diagnosis of alpha-1 antitrypsin deficiency which will serve as an innovative genetic test enabling precise and early detection. These factors are driving the demand of alpha-1 antitrypsin deficiency (AATD) augmentation therapy market in the North American region.

Competitive Landscape

The report provides both, qualitative and quantitative research of global alpha-1 antitrypsin deficiency (AATD) augmentation therapy market, as well as provides comprehensive insights and development methods adopted by the key contenders. The report also offers extensive research on the key players in this market and details on the competitiveness of these players. Key business strategies such as mergers and acquisitions (M&A), affiliations, collaborations, and contracts adopted by these major market participants are also recognized and analysed in the report. For each company, the report studies their global presence, competitors, service offerings and specification amongst others.

Global Alpha-1 Antitrypsin Deficiency (AATD) Augmentation Therapy Market

By End-User

  • Hospitals and Clinics
  • Physicians Office
  • Outpatient Infusion Centers
  • Others

By Application

  • Emphysema
  • Alpha-1
  • Others

By Recommended Dose

  • 60 mg/kg IV (Weekly)
  • Others

By Geography

  • North America
    • US
    • Canada
    • Mexico
    • Rest of North America
  • Europe
    • France
    • The UK
    • Spain
    • Germany
    • Italy
    • Nordic Countries
      • Denmark
      • Finland
      • Iceland
      • Sweden
      • Norway
    • Benelux Union
      • Belgium
      • The Netherlands
      • Luxembourg
    • Rest of Europe
  • Asia Pacific
    • China
    • Japan
    • India
    • New Zealand
    • Australia
    • South Korea
    • Southeast Asia
      • Indonesia
      • Thailand
      • Malaysia
      • Singapore
      • Rest of Southeast Asia
    • Rest of Asia Pacific 
  • Middle East and Africa
    • Saudi Arabia
    • UAE
    • Egypt
    • Kuwait
    • South Africa
    • Rest of Middle East & Africa
  • Latin America
    • Brazil
    • Argentina
    • Rest of Latin America

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