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  • Recently, researchers have begun to put together a more comprehensive picture surrounding the “central dogma” of molecular biology, leading to the revelation that RNA is not just a simple genetic messenger, but rather a complex signaling molecule which is present in an increasing number of structural forms. A variety of iterations in which RNA exists allow the molecule to function as the template for translating the genetic code into protein, as the post-transcriptional regulator and the gene silencer, additionally, as recently discovered, a modulator of epigenetic elements.

    Specific classes of non-coding RNA (ncRNA) ―short RNAs (including micro RNA (miRNA), short interfering RNA (siRNA), and piwi-interacting RNA (piRNA)) and long non-coding RNAs (lncRNA)―regulate gene expression through epigenetic mechanisms, influencing several cellular processes, such as X chromosome inactivation, genomic imprinting, some cellular processes, and cancer. LncRNAs tether epigenetic complexes that are capable of methylating DNA and modifying histones to the chromatin, thereby enabling allele and locus-specific regulation. Moreover, lncRNAs, because of their length, are suited for orchestrating specific regulatory events particular to a target locus. In addition, miRNA has shown to be linked with cancer and can act as oncogenes or tumor-suppressor genes. They can be involved in establishing DNA methylation and regulating histone modification through interacting with their target mRNA to alter chromatin of the corresponding DNA template.

    https://www.creative-biogene.com/services/rna-seq-profiling-services.html
    Recently, researchers have begun to put together a more comprehensive picture surrounding the “central dogma” of molecular biology, leading to the revelation that RNA is not just a simple genetic messenger, but rather a complex signaling molecule which is present in an increasing number of structural forms. A variety of iterations in which RNA exists allow the molecule to function as the template for translating the genetic code into protein, as the post-transcriptional regulator and the gene silencer, additionally, as recently discovered, a modulator of epigenetic elements. Specific classes of non-coding RNA (ncRNA) ―short RNAs (including micro RNA (miRNA), short interfering RNA (siRNA), and piwi-interacting RNA (piRNA)) and long non-coding RNAs (lncRNA)―regulate gene expression through epigenetic mechanisms, influencing several cellular processes, such as X chromosome inactivation, genomic imprinting, some cellular processes, and cancer. LncRNAs tether epigenetic complexes that are capable of methylating DNA and modifying histones to the chromatin, thereby enabling allele and locus-specific regulation. Moreover, lncRNAs, because of their length, are suited for orchestrating specific regulatory events particular to a target locus. In addition, miRNA has shown to be linked with cancer and can act as oncogenes or tumor-suppressor genes. They can be involved in establishing DNA methylation and regulating histone modification through interacting with their target mRNA to alter chromatin of the corresponding DNA template. https://www.creative-biogene.com/services/rna-seq-profiling-services.html
    RNA-seq Profiling Services - Creative Biogene
    Creative Biogene is able to offer a comprehensive range of RNA-seq profiling services to uncover the presence and quantity of RNA for gene expression profiling across the transcriptome.
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  • Epigenomic technologies enable us to look beyond the genome sequence, revealing information about how the genome actually exists in individual cells, including bound by proteins, modified by enzymes, and folded inside the dynamic 3-dimensional space of the cell's nucleus. This epigenetic information is important for understanding how each cell type in the human body functions during normal development, and how their function goes amiss in disease.

    Creative Biogene, as one of the leading biotechnology companies, is able to offer comprehensive epigenomics profiling services to help researchers explore the function of various aspects of the epigenome in the context of human biology and disease. These aspects include histone modification, transcription factor binding, chromatin accessibility, and 3D chromatin architecture, in both bulk samples and in single-cell resolution.

    https://www.creative-biogene.com/services/epigenomics-profiling-services.html
    Epigenomic technologies enable us to look beyond the genome sequence, revealing information about how the genome actually exists in individual cells, including bound by proteins, modified by enzymes, and folded inside the dynamic 3-dimensional space of the cell's nucleus. This epigenetic information is important for understanding how each cell type in the human body functions during normal development, and how their function goes amiss in disease. Creative Biogene, as one of the leading biotechnology companies, is able to offer comprehensive epigenomics profiling services to help researchers explore the function of various aspects of the epigenome in the context of human biology and disease. These aspects include histone modification, transcription factor binding, chromatin accessibility, and 3D chromatin architecture, in both bulk samples and in single-cell resolution. https://www.creative-biogene.com/services/epigenomics-profiling-services.html
    Epigenomics Profiling Services - Creative Biogene
    Creative Biogene can provide epigenome-wide analyses for understanding epigenetic mechanisms, transgenerational epigenetics studies, epigenetics-related drug discovery, and functional epigenomics.
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  • For a decade or more, Creative Biogene has been synthesizing oligonucleotides for a variety of research applications. Our facilities are particularly designed for large volume custom production, incorporating automation to ensure consistent production. Our oligos are not only of the highest standard but also the most competitive in the industry, especially for high purity and modified oligos. This is because we manufacture the majority of our reagents and tools in-house.

    Our catalogue portfolio of pre-designed oligonucleotides includes LncRNA qPCR assay products and CpG ODN. And we can also provide Custom miRNA qPCR Primers Set for profiling miRNome expression, cancer, and disease-related miRNAs of human and mouse.

    https://www.creative-biogene.com/products/oligonucleotide-products.html
    For a decade or more, Creative Biogene has been synthesizing oligonucleotides for a variety of research applications. Our facilities are particularly designed for large volume custom production, incorporating automation to ensure consistent production. Our oligos are not only of the highest standard but also the most competitive in the industry, especially for high purity and modified oligos. This is because we manufacture the majority of our reagents and tools in-house. Our catalogue portfolio of pre-designed oligonucleotides includes LncRNA qPCR assay products and CpG ODN. And we can also provide Custom miRNA qPCR Primers Set for profiling miRNome expression, cancer, and disease-related miRNAs of human and mouse. https://www.creative-biogene.com/products/oligonucleotide-products.html
    Oligonucleotide Products - Creative Biogene
    Our catalog portfolio of pre-designed oligonucleotides includes lncRNA qPCR assay products and CpG ODN.
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  • Gene Knockin Mouse Generation
    CRISPR/Cas9 PlatformCB provides a knockin mice generation service, including point mutation mice, ROSA26 knockin mice, custom knockin mice and conditional knockin mice. With years of experience and expertise, our staff will show you a reliable strategy for your case after analysis the situation. We will work closely with you to design and deliver a genetically engineered mouse model to...
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  • CRISPR Library Screening
    As a leader of CRISPR product manufacturer, Creative Biogene CRISPR/Cas9 Platform offers a comprehensive CRISPR library screening service and sgRNA library products for clients. With leading-edge technology and excellent platform, our experienced scientists are expert in CRISPR library screening. In order to fulfill different requirements, CRISPR/Cas9 PlatformCB has developed various...
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  • Genome Editing in Plants
    CRISPR/Cas9 PlatformCB offers a one-stop plant genome editing service, including gene knockout, gene knockin and gene deletion. Various species are available for this service, including but not limited to Arabidopsis thaliana, Zea mays, rice and tobacco. With excellent platform, our experienced scientists are dedicated to providing a reliable and satisfied service for our...
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  • Point Mutation Mouse
    Point mutant mice are gene knockout mouse models in which one or more nucleotides are replaced by mutant nucleotides in the mouse genome. This may result in amino acid changes within the protein sequence, and transcription terminated, thereby significantly affecting the normal function of the protein. Point mutation mouse models are widely used to study the role of specific nucleotides or amino...
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  • https://www.creative-biogene.com/Services/Drug-Discovery-Services/Kinase-Screening-and-Profiling-with-Biochemical-Assays.html
    https://www.creative-biogene.com/Services/Drug-Discovery-Services/Kinase-Screening-and-Profiling-with-Biochemical-Assays.html
    Kinase Screening and Profiling with Biochemical Assays - Creative Biogene
    Our service development comprises routine assay optimization (including enzyme titration, time course, Km determination etc.) and assay validation (such as DMSO tolerance, Z' test, compound validation, etc.).
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  • Utilizing Zebrafish Genome Editing Services: Shaping the Future of Genomic Research
    Within the rapidly advancing realm of biotechnology, zebrafish genome editing services are carving a niche, heralding a new epoch in genomics and cellular research. This development is driving innovative research approaches, empowering researchers to create effective models to comprehend complex genetic interactions and responses quickly and efficiently.   Zebrafish, also known as Danio...
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  • Pioneering Developments in Lipid Nanoparticle Formulation Services: A Biotechnological Breakthrough
    The biotechnological sector has witnessed numerous paradigm shifts in recent years as transformative innovations continue to fortify its existing areas of operation. One such ground-breaking advancement is the development and formulation of lipid nanoparticles (LNPs) — defining the future of targeted drug delivery systems.   Nanotechnology has significantly broadened its horizon in...
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