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  • GENERAL TARGETS OF RIBOSOME
    General Targets of Ribosome Decoding Center The decoding center (DC) is the region comprising the A site on the 30S subunit that monitors the correct base pairing between the mRNA codon and the anticodon of the aa-tRNA. This part of the ribosome consists of regions of the 30S head and shoulder, and the top of helix 44 (h44) of 16S rRNA. Antibiotics belonging to several different chemical...
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  • Patient Genome Sequencing
    Next-generation sequencing (NGS) is a technique that can fundamentally change the perception of scientific and diagnostic issues. This technology produces large amounts of sequencing data at a lower price point, leading to a series of breakthroughs and unfolding a new era of bioinformatics and biostatistical data analysis. Creative Biolabs is a leading provider of genomic services. The...
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  • Fc-Fusion Protein Development
    IgG molecules of the IgG1, IgG2, and IgG4 subclasses exhibit exceptionally long half-lives due to FcRn-mediated recycling. Half-lives of up to 4 weeks have been described for therapeutic antibodies. The binding site for FcRn resides in the Fc region, which is formed by the CH2 and CH3 domains. Thus, fusion to an Fcγ region endows a therapeutic protein with the half-life extension...
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  • Cancer Therapy by Exosome
    Cancer remains one of the leading causes of death due to its late diagnosis, poor prognosis, and frequent occurrence of drug resistance and metastasis. Cancer therapy by exosomes transfer bioactive molecules between cancer and other cells and modulate the biological functions of recipient cells, thus participating in the progression and metastasis of multiple cancers. Exosomes, as an important...
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  • "The human 80S ribosome is composed of a 40S and a 60S subunit. The chief function of the 40S subunit, which contains one strand of 18S ribosomal RNA (rRNA) and 33 distinct RPs, is to bind, unwind and scan mRNAs, whereas the 60S subunit is responsible for peptide bond formation and quality control of nascent peptides and is composed of three strands of rRNA (5S, 5.8S and 28S rRNA) and 47 distinct RPs," cited from https://ribosome.creative-biolabs.com/ribosome-in-neurological-disease.htm.
    "The human 80S ribosome is composed of a 40S and a 60S subunit. The chief function of the 40S subunit, which contains one strand of 18S ribosomal RNA (rRNA) and 33 distinct RPs, is to bind, unwind and scan mRNAs, whereas the 60S subunit is responsible for peptide bond formation and quality control of nascent peptides and is composed of three strands of rRNA (5S, 5.8S and 28S rRNA) and 47 distinct RPs," cited from https://ribosome.creative-biolabs.com/ribosome-in-neurological-disease.htm.
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  • The developing pathogen Franciscella tularensis (F. tularensis), which belongs to the francisellaceae family, travels quickly via the blood and respiratory system. It has been identified as the primary cause of tularemia and is an aerobic Gram-negative bacterium.
    For more: https://non-igg-ab.creative-biolabs.com/non-igg-antibodies-development-for-franciscella-tularensis-infection-therapy.htm
    The developing pathogen Franciscella tularensis (F. tularensis), which belongs to the francisellaceae family, travels quickly via the blood and respiratory system. It has been identified as the primary cause of tularemia and is an aerobic Gram-negative bacterium. For more: https://non-igg-ab.creative-biolabs.com/non-igg-antibodies-development-for-franciscella-tularensis-infection-therapy.htm
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  • Flow cytometry (FCM or FC) is an impedance-based biophysical technology that is invented for cell sorting, cell counting, biomarker detection, protein engineering and so on. The FCM machine makes use of suspending cells in a stream of fluid to pass through an electronic apparatus and then collect quantities of data or parameters. (resource from https://www.creative-biolabs.com/drug-discovery/diagnostics/flow-cytometry-based-kits-development.htm)
    Flow cytometry (FCM or FC) is an impedance-based biophysical technology that is invented for cell sorting, cell counting, biomarker detection, protein engineering and so on. The FCM machine makes use of suspending cells in a stream of fluid to pass through an electronic apparatus and then collect quantities of data or parameters. (resource from https://www.creative-biolabs.com/drug-discovery/diagnostics/flow-cytometry-based-kits-development.htm)
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  • The most effective means to develop half-life assay animal models is humanizing domesticated mouse strains, usually by genetic modification or organ transplantation.
    For more: https://half-life-extension.creative-biolabs.com/animal-models-development-for-half-life-assay.htm
    The most effective means to develop half-life assay animal models is humanizing domesticated mouse strains, usually by genetic modification or organ transplantation. For more: https://half-life-extension.creative-biolabs.com/animal-models-development-for-half-life-assay.htm
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  • To trigger an efficient immune response, synthetic antigens are commonly linked to an immunogenic carrier protein. Since tetanus toxoid contains potent T-helper cell epitopes, which initiate T-helper cell stimulation and widely used in human medicine, it is a suitable carrier for the glycopeptide conjugate. (Cited from https://www.creative-biolabs.com/glycoprotein/glycopeptide-based-cancer-vaccine-development.htm)
    To trigger an efficient immune response, synthetic antigens are commonly linked to an immunogenic carrier protein. Since tetanus toxoid contains potent T-helper cell epitopes, which initiate T-helper cell stimulation and widely used in human medicine, it is a suitable carrier for the glycopeptide conjugate. (Cited from https://www.creative-biolabs.com/glycoprotein/glycopeptide-based-cancer-vaccine-development.htm)
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  • "Captured proteins are visualized using chemiluminescent or Laser Scanner. The signal produced is proportional to the amount of analyte bound. The Mouse Growth Factor Antibody Array detects 30 Mouse Growth Factors. It is suitable for all liquid sample types," cited from https://www.antibody-creativebiolabs.com/growth-factor-antibody-array-626040.htm.
    "Captured proteins are visualized using chemiluminescent or Laser Scanner. The signal produced is proportional to the amount of analyte bound. The Mouse Growth Factor Antibody Array detects 30 Mouse Growth Factors. It is suitable for all liquid sample types," cited from https://www.antibody-creativebiolabs.com/growth-factor-antibody-array-626040.htm.
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